MyBioSource.com's SFTPB Antibody (Center) is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: ELISA, and Western Blot. The SFTPB Antibody (Center) was generated using SFTP3, Sftpb, spb, and Surfactant Protein B as the antigen and it reacts with Human.
Description
SFTPB is the pulmonary-associated surfactant
protein B (SPB), an amphipathic surfactant protein essential for
lung function and homeostasis after birth. Pulmonary surfactant is
a surface-active lipoprotein complex composed of 90% lipids and 10%
proteins which include plasma proteins and apolipoproteins SPA,
SPB, SPC and SPD. The surfactant is secreted by the alveolar cells
of the lung and maintains the stability of pulmonary tissue by
reducing the surface tension of fluids that coat the lung. The SPB
enhances the rate of spreading and increases the stability of
surfactant monolayers in vitro. Multiple mutations in this gene
have been identified, which cause pulmonary surfactant metabolism
dysfunction type 1, also called pulmonary alveolar proteinosis due
to surfactant protein B deficiency, and are associated with fatal
respiratory distress in the neonatal period. Alternatively spliced
transcript variants encoding the same protein have been identified